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A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review

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Cell Biology and Translational Medicine, Volume 11

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1312))

Abstract

Stem cell-based therapy stands as a robust experimental treatment for ischemic stroke. Stem cells derived from fetal, embryonic, and adult tissues serve as potential sources for transplantable cells in the setting of ischemic stroke. However, the search continues for finding an optimal cell line for clinical use. Muse cells, a distinct subset of mesenchymal stem cells found sporadically in the connective tissue of nearly every organ, may be a suitable candidate due to its safety and accessibility. These cells have been investigated for therapeutic usage in chronic kidney disease, liver disease, acute myocardial infarction, and stroke. Muse cells display the ability to engraft and differentiate into the host neural network unlike many other cell lines which only display bystander immunomodulating effects. Taking advantage of this unique engraftment and differentiation mechanism behind Muse cells’ therapeutic effects on the central nervous system, as well as other organ systems, will undoubtedly advance the cells’ utility for cell-based regenerative medicine in stroke.

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Authors and Affiliations

  1. Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA

    You Jeong Park, Jeffrey Farooq, Justin Cho, Blaise Cozene, Bella Gonzales-Portillo, Nadia Sadanandan, Madeline Saft, Jea Young Lee & Cesar V. Borlongan

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  1. You Jeong Park
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  2. Jeffrey Farooq
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Correspondence to Cesar V. Borlongan .

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  1. (emeritus), Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Park, Y.J. et al. (2020). A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 11. Advances in Experimental Medicine and Biology(), vol 1312. Springer, Cham. https://doi.org/10.1007/5584_2020_596

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