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Functions of Mesenchymal Stem Cells in Cardiac Repair

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Cell Biology and Translational Medicine, Volume 11

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1312))

Abstract

Myocardial infarction (MI) and heart failure (HF) are significant contributors of mortality worldwide. Mesenchymal stem cells (MSCs) hold a great potential for cardiac regenerative medicine-based therapies. Their therapeutic potential has been widely investigated in various in-vitro and in-vivo preclinical models. Besides, they have been tested in clinical trials of MI and HF with various outcomes. Differentiation to lineages of cardiac cells, neovascularization, anti-fibrotic, anti-inflammatory, anti-apoptotic and immune modulatory effects are the main drivers of MSC functions during cardiac repair. However, the main mechanisms regulating these functions and cross-talk between cells are not fully known yet. Increasing line of evidence also suggests that secretomes of MSCs and/or their extracellular vesicles play significant roles in a paracrine manner while mediating these functions. This chapter aims to summarize and highlight cardiac repair functions of MSCs during cardiac repair.

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Acknowledgments

The figures were created with the support of BioRender.com.

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Authors and Affiliations

  1. Faculty of Science, Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University, Ankara, Turkey

    Selçuk Öztürk & Yaşar Murat Elçin

  2. Faculty of Medicine, Department of Cardiology, Yozgat Bozok University, Yozgat, Turkey

    Selçuk Öztürk

  3. Faculty of Science, and Ankara University Stem Cell Institute, Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University, Ankara, Turkey

    Ayşe Eser Elçin

  4. Biovalda Health Technologies, Inc., Ankara, Turkey

    Yaşar Murat Elçin

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  1. Selçuk Öztürk
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  2. Ayşe Eser Elçin
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Correspondence to Yaşar Murat Elçin .

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  1. (emeritus), Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Öztürk, S., Elçin, A.E., Elçin, Y.M. (2020). Functions of Mesenchymal Stem Cells in Cardiac Repair. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 11. Advances in Experimental Medicine and Biology(), vol 1312. Springer, Cham. https://doi.org/10.1007/5584_2020_598

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