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Extracellular Vesicle Therapeutics in Regenerative Medicine

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Cell Biology and Translational Medicine, Volume 11

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1312))

Abstract

Extracellular vesicles (EVs) are nano-sized, cell-released vesicles which contain lipids, proteins, and nucleic acids derived from the parental cells. EVs play an important role in intercellular communication and influence both physiological and pathological conditions. They are increasingly explored as potential therapeutic agents since they can cross biological barriers, their cargo is protected from degradation and they are involved in the transfer of bioactive components. EVs can promote tissue regeneration and might be alternatives to cell therapy. They can be used both in their native form, and as delivery vehicles for therapeutic agents. However, there are many hurdles to overcome for broad clinical application of EVs as therapeutics. Here, we review recent conditions regarding EVs therapeutics in regenerative medicine.

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Abbreviations

EV:

Extracellular vesicle

MSC:

Mesenchymal stromal cell

CNS:

Central nervous system

GvHD:

Graft versus host disease

iPSC:

Induced pluripotent stem cell

SEC:

Size-exclusion chromatography

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Disclosure Statement

Aya Imafuku and Sebastian Sjoqvist are founders and owners of ExTherea Inc., Kanagawa, Japan. Sebastian Sjoqvist is employed by Takeda Pharmaceuticals.

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Authors and Affiliations

  1. ExTherea Inc, Fujisawa, Kanagawa, Japan

    Aya Imafuku & Sebastian Sjoqvist

  2. Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden

    Sebastian Sjoqvist

Authors
  1. Aya Imafuku
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  2. Sebastian Sjoqvist
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Corresponding author

Correspondence to Sebastian Sjoqvist .

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Editors and Affiliations

  1. (emeritus), Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Imafuku, A., Sjoqvist, S. (2020). Extracellular Vesicle Therapeutics in Regenerative Medicine. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 11. Advances in Experimental Medicine and Biology(), vol 1312. Springer, Cham. https://doi.org/10.1007/5584_2020_599

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