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Hypertensive Urgency and Emergency: Diagnostic and Therapeutic Considerations

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Hypertension and Cardiovascular Disease in Asia

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

Hypertensive emergency and urgency is often termed ‘hypertensive crisis’. However, the terms reflect a spectrum ranging from hypertensive urgency (a spike in blood pressure [BP; >180/110 mmHg] without any target organ damage) to hypertensive emergency where BP is so high that there is imminent threat of target organ damage (e.g., acute cerebrovascular, cardiovascular, ophthalmic, or renal events). A clinical distinction between the two conditions helps with risk stratification in individual patients. Those with hypertensive emergency need hospital admission and initial treatment with parenteral antihypertensive agents, while those with hypertensive urgency can be managed with oral antihypertensives on an outpatient basis. This chapter describes the clinical spectrum of these conditions and treatment choices.

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References

  1. Muiesan ML, Salvetti M, Amadoro V, di Somma S, Perlini S, Semplicini A, et al. An update on hypertensive emergencies and urgencies. J Cardiovasc Med. 2015;16(5):372–82.

    Article  Google Scholar 

  2. Wolf SJ, Lo B, Shih RD, Smith MD, Fesmire FM. Clinical policy: critical issues in the evaluation and management of adult patients in the emergency department with asymptomatic elevated blood pressure. Ann Emerg Med. 2013;62(1):59–68.

    Article  PubMed  Google Scholar 

  3. Astarita A, Covella M, Vallelonga F, Cesareo M, Totaro S, Ventre L, et al. Hypertensive emergencies and urgencies in emergency departments: a systematic review and meta-analysis. J Hypertens. 2020;38(7):1203–10.

    Article  CAS  PubMed  Google Scholar 

  4. Rubin S, Cremer A, Boulestreau R, Rigothier C, Kuntz S, Gosse P. Malignant hypertension: diagnosis, treatment and prognosis with experience from the Bordeaux cohort. J Hypertens. 2019;37(2):316–24.

    Article  CAS  PubMed  Google Scholar 

  5. Domek M, Gumprecht J, Lip GYH, Shantsila A. Malignant hypertension: does this still exist? J Hum Hypertens. 2020;34(1):1–4.

    Article  PubMed  Google Scholar 

  6. Elliott WJ. Clinical features in the management of selected hypertensive emergencies. Prog Cardiovasc Dis. 2006;48(5):316–25.

    Article  PubMed  Google Scholar 

  7. Zampaglione B, Pascale C, Marchisio M, Cavallo-Perin P. Hypertensive urgencies and emergencies. Prevalence and clinical presentation. Hypertension. 1996;27(1):144–7.

    Article  CAS  PubMed  Google Scholar 

  8. Rosei EA, Salvetti M, Farsang C. European Society of Hypertension Scientific Newsletter: treatment of hypertensive urgencies and emergencies. J Hypertens. 2006;24(12):2482–5.

    Article  CAS  PubMed  Google Scholar 

  9. Varounis C, Katsi V, Nihoyannopoulos P, Lekakis J, Tousoulis D. Cardiovascular hypertensive crisis: recent evidence and review of the literature. Front Cardiovasc Med. 2017;3:51.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Ault MJ, Ellrodt AG. Pathophysiological events leading to the end-organ effects of acute hypertension. Am J Emerg Med. 1985;3(6):10–5.

    Article  CAS  PubMed  Google Scholar 

  11. Adebayo O, Rogers RL. Hypertensive emergencies in the emergency department. Emerg Med Clin North Am. 2015;33(3):539–51.

    Article  PubMed  Google Scholar 

  12. Paini A, Tarozzi L, Bertacchini F, Aggiusti C, Rosei CA, De Ciuceis C, et al. Cardiovascular prognosis in patients admitted to an emergency department with hypertensive emergencies and urgencies. J Hypertens. 2021;39(12):2514–20.

    Article  CAS  PubMed  Google Scholar 

  13. Freis ED, Arias LA, Armstrong ML, Blount AW, Calabresi M, Castle CH, et al. Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA. 1967;202(11):1028–34.

    Article  Google Scholar 

  14. Levy PD, Mahn JJ, Miller J, Shelby A, Brody A, Davidson R, et al. Blood pressure treatment and outcomes in hypertensive patients without acute target organ damage: a retrospective cohort. Am J Emerg Med. 2015;33(9):1219–24.

    Article  PubMed  Google Scholar 

  15. Patel KK, Young L, Howell EH, Hu B, Rutecki G, Thomas G, et al. Characteristics and outcomes of patients presenting with hypertensive urgency in the office setting. JAMA Intern Med. 2016;176(7):981–8.

    Article  PubMed  Google Scholar 

  16. Kaplan NM. Chapter 8: hypertensive emergencies. In: Kaplan NM, Victor RG, editors. Kaplan’s clinical hypertension. 11th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2015. p. 263.

    Google Scholar 

  17. DeFelice A, Willard J, Lawrence J, Hung J, Gordon MA, Karkowsky A, et al. The risks associated with short-term placebo-controlled antihypertensive clinical trials: a descriptive meta-analysis. J Hum Hypertens. 2008;22(10):659–68.

    Article  CAS  PubMed  Google Scholar 

  18. Rodriguez MA, Kumar SK, De Caro M. Hypertensive crisis. Cardiol Rev. 2010;18(2):102–7.

    Article  PubMed  Google Scholar 

  19. Johnson W, Nguyen ML, Patel R. Hypertension crisis in the emergency department. Cardiol Clin. 2012;30(4):533–43.

    Article  PubMed  Google Scholar 

  20. Gifford RW. Management of hypertensive crises. JAMA. 1991;266(6):829–35.

    Article  PubMed  Google Scholar 

  21. Ruland S, Aiyagari V. Cerebral autoregulation and blood pressure lowering. Hypertension. 2007;49(5):977–8.

    Article  CAS  PubMed  Google Scholar 

  22. Kaplan NM. Management of hypertensive emergencies. Lancet. 1994;344(8933):1335–8.

    Article  CAS  PubMed  Google Scholar 

  23. Cremer A, Amraoui F, Lip GY, Morales E, Rubin S, Segura J, Van den Born BJ, Gosse P. From malignant hypertension to hypertension-MOD: a modern definition for an old but still dangerous emergency. J Hum Hypertens. 2016;30(8):463–6.

    Article  CAS  PubMed  Google Scholar 

  24. Shantsila A, Dwivedi G, Shantsila E, Butt M, Beevers DG, Lip GY. Persistent macrovascular and microvascular dysfunction in patients with malignant hypertension. Hypertension. 2011;57(3):490–6.

    Article  CAS  PubMed  Google Scholar 

  25. Marik PE, Varon J. Hypertensive crises: challenges and management. Chest. 2007;131(6):1949–62.

    Article  CAS  PubMed  Google Scholar 

  26. Hollander JE. Cocaine intoxication and hypertension. Ann Emerg Med. 2008;51(3):18–20.

    Article  Google Scholar 

  27. Ram CV, Silverstein RL. Treatment of hypertensive urgencies and emergencies. Curr Hypertens Rep. 2009;11(5):307–14.

    Article  PubMed  Google Scholar 

  28. van der Veen PH, Geerlings MI, Visseren FL, Nathoe HM, Mali WP, van der Graaf Y, et al. Hypertensive target organ damage and longitudinal changes in brain structure and function: the second manifestations of arterial disease-magnetic resonance study. Hypertension. 2015;66(6):1152–8.

    Article  PubMed  CAS  Google Scholar 

  29. Grassi D, O’Flaherty M, Pellizzari M, Bendersky M, Rodriguez P, Turri D, et al. Hypertensive urgencies in the emergency department: evaluating blood pressure response to rest and to antihypertensive drugs with different profiles. J Clin Hypertens. 2008;10(9):662–7.

    Article  Google Scholar 

  30. Neutel JM, Smith DH, Wallin D, Cook E, Ram CV, Fletcher E, Maher KE, Turlepaty P, Grandy S, Lee R, et al. A comparison of intravenous nicardipine and sodium nitroprusside in the immediate treatment of severe hypertension. Am J Hypertens. 1994;7(7):623–8.

    Article  CAS  PubMed  Google Scholar 

  31. Perez MI, Musini VM. Pharmacological interventions for hypertensive emergencies: a Cochrane systematic review. J Hum Hypertens. 2008;22(9):596–607.

    Article  CAS  PubMed  Google Scholar 

  32. Abdelwahab W, Frishman W, Landau A. Management of hypertensive urgencies and emergencies. J Clin Pharmacol. 1995;35(8):747–62.

    Article  CAS  PubMed  Google Scholar 

  33. Hsieh YT, Lee TY, Kao JS, Hsu HL, Chong CF. Treating acute hypertensive cardiogenic pulmonary edema with high-dose nitroglycerin. Turk J Emerg Med. 2018;18(1):34–6.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Varon J. Treatment of acute severe hypertension: current and newer agents. Drugs. 2008;68(3):283–97.

    Article  CAS  PubMed  Google Scholar 

  35. Padilla Ramos A, Varon J. Current and newer agents for hypertensive emergencies. Curr Hypertens Rep. 2014;16(7):450.

    Article  PubMed  CAS  Google Scholar 

  36. Peacock WF, Varon J, Baumann BM, Borczuk P, Cannon CM, Chandra A, et al. CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department. Crit Care. 2011;15(3):157.

    Article  Google Scholar 

  37. Hirschl MM, Binder M, Bur A, Herkner H, Brunner M, Müllner M, et al. Clinical evaluation of different doses of intravenous enalaprilat in patients with hypertensive crises. Arch Intern Med. 1995;155(20):2217–23.

    Article  CAS  PubMed  Google Scholar 

  38. Campbell P, Baker WL, Bendel SD, White WB. Intravenous hydralazine for blood pressure management in the hospitalized patient: its use is often unjustified. J Am Soc Hypertens. 2011;5(6):473–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Gupta PK, Gupta H, Khoynezhad A. Hypertensive emergency in aortic dissection and thoracic aortic aneurysm-a review of management. Pharmaceuticals. 2009;2(3):66–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, Casey DE, et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2010;121(13):266–369.

    Google Scholar 

  41. Papaioannou TG, Stefanadis C. Vascular wall shear stress: basic principles and methods. Hell J Cardiol. 2005;46(1):9–15.

    Google Scholar 

  42. Picariello C, Lazzeri C, Attanà P, Chiostri M, Gensini GF, Valente S. The impact of hypertension on patients with acute coronary syndromes. Int J Hypertens. 2011;2011:563657.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Ahmed N, Wahlgren N, Brainin M, Castillo J, Ford GA, Kaste M, et al. Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from safe implementation of thrombolysis in stroke-international stroke thrombolysis register (SITS-ISTR). Stroke. 2009;40(7):2442–9.

    Article  PubMed  Google Scholar 

  44. Figueroa SA, Zhao W, Aiyagari V. Emergency and critical care management of acute ischaemic stroke. CNS Drugs. 2015;29(1):17–28.

    Article  PubMed  Google Scholar 

  45. Anderson CS, Heeley E, Huang Y, Wang J, Stapf C, Delcourt C, Lindley R, Robinson T, Lavados P, Neal B, Hata J, Arima H, Parsons M, Li Y, Wang J, Heritier S, Li Q, Woodward M, Simes RJ, Davis SM, Chalmers J. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med. 2013;368(25):2355–65.

    Article  CAS  PubMed  Google Scholar 

  46. Qureshi AI, Palesch YY, Barsan WG, Hanley DF, Hsu CY, Martin RL, et al. Intensive blood-pressure lowering in patients with acute cerebral hemorrhage. N Engl J Med. 2016;375(11):1033–43.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Reed WG, Anderson RJ. Effects of rapid blood pressure reduction on cerebral blood flow. Am Heart J. 1986;111(1):226–8.

    Article  CAS  PubMed  Google Scholar 

  48. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol. 2003;102(1):181–92.

    PubMed  Google Scholar 

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Nair, T. (2022). Hypertensive Urgency and Emergency: Diagnostic and Therapeutic Considerations. In: Ram, C.V.S., Teo, B.W.J., Wander, G.S. (eds) Hypertension and Cardiovascular Disease in Asia. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-030-95734-6_26

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  • DOI: https://doi.org/10.1007/978-3-030-95734-6_26

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  • Online ISBN: 978-3-030-95734-6

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