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Relation of Genetics and Obesity with Hypertension: An Asian Perspective

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Hypertension and Cardiovascular Disease in Asia

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

Genetic factors are important in hypertension pathophysiology and several genes and polymorphisms that predispose to hypertension and its complications have been identified by genome-wide association studies. However, there are limited hypertension genome-wide and candidate-gene association studies in Asia, and the majority come from East Asian countries. Most of the polymorphisms identified are identical to those in European populations and more studies are needed. Hypertension polygenic risk scores are being evaluated for identification of hypertension risk and early aggressive management. Generalized and abdominal obesity are important hypertension risk factors and are widely prevalent in most Asian countries. Asia-specific hypertension pharmacogenomics and other management strategies, including technology, need further evaluation. A social determinants approach to hypertension management is important to ameliorate multiple hypertension risk factors.

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Authors and Affiliations

  1. Department of Preventive Cardiology and Internal Medicine, Eternal Heart Care Centre and Research Institute, Mount Sinai New York Affiliate, Jaipur, India

    Rajeev Gupta

  2. Academic Research Development Unit, Rajasthan University of Health Sciences, Jaipur, India

    Rajeev Gupta

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  1. Rajeev Gupta
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Correspondence to Rajeev Gupta .

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Editors and Affiliations

  1. Apollo Hospitals, Apollo Institute for Blood Pressure Management, Hyderabad, India

    C. Venkata S. Ram

  2. Head, Division of Nephrology Department of Medicine, Yong Loo Lin Sch of Med Natl Univ of Sin, Singapore, Singapore

    Boon Wee Jimmy Teo

  3. Department of Cardiology, Hero DMC Heart Institute, Dayanand Medical College, Ludhiana, Punjab, India

    Gurpreet S. Wander

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Gupta, R. (2022). Relation of Genetics and Obesity with Hypertension: An Asian Perspective. In: Ram, C.V.S., Teo, B.W.J., Wander, G.S. (eds) Hypertension and Cardiovascular Disease in Asia. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-030-95734-6_6

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  • DOI: https://doi.org/10.1007/978-3-030-95734-6_6

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